Discrete roles of Ir76b ionotropic coreceptor impact olfaction, blood feeding, and mating in the malaria vector mosquito Anopheles coluzzii

Author:

Ye Zi1,Liu Feng1,Sun Huahua1ORCID,Ferguson Stephen T.1ORCID,Baker Adam1ORCID,Ochieng Samuel A.1ORCID,Zwiebel Laurence J.1ORCID

Affiliation:

1. Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235

Abstract

Significance Chemosensory systems play crucial roles across mosquito life cycles, with underlying molecular receptors often forming functional complexes that require cognate coreceptors. To better understand chemosensory pathways in the malaria vector mosquito Anopheles coluzzii , gene editing were used to localize and functionally characterize the ionotropic receptor coreceptor AcIr76b . Expression of AcIr76b was observed in antennal grooved pegs, coeloconic sensilla, and other accessory olfactory appendages. When AcIr76b was inactivated, mutant mosquitoes displayed altered neuronal responses to amines.. Beyond olfactory phenotypes, AcIr76b mutants display significantly impaired mating and blood feeding capabilities. Our data reveal discrete roles of AcIr76b across chemosensory pathways, suggesting ionotropic pathways as targets for the design of vector control strategies.

Funder

HHS | NIH | Office of Extramural Research, National Institutes of Health

Vanderbilt University

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3