Affiliation:
1. Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235
Abstract
Significance
Chemosensory systems play crucial roles across mosquito life cycles, with underlying molecular receptors often forming functional complexes that require cognate coreceptors. To better understand chemosensory pathways in the malaria vector mosquito
Anopheles coluzzii
, gene editing were used to localize and functionally characterize the ionotropic receptor coreceptor
AcIr76b
. Expression of
AcIr76b
was observed in antennal grooved pegs, coeloconic sensilla, and other accessory olfactory appendages. When
AcIr76b
was inactivated, mutant mosquitoes displayed altered neuronal responses to amines.. Beyond olfactory phenotypes,
AcIr76b
mutants display significantly impaired mating and blood feeding capabilities. Our data reveal discrete roles of
AcIr76b
across chemosensory pathways, suggesting ionotropic pathways as targets for the design of vector control strategies.
Funder
HHS | NIH | Office of Extramural Research, National Institutes of Health
Vanderbilt University
Publisher
Proceedings of the National Academy of Sciences
Cited by
13 articles.
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