Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis-Reference-Cited by-同舟云学术

Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis

Published:2022-03-08 Issue:11 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Zhang Shuai¹²,Nelson Ornella D.²,Price Ian R.²^ORCID,Zhu Chengliang²^ORCID,Lu Xuan²,Fernandez Irma R.²³,Weiss Robert S.³^ORCID,Lin Hening¹²^ORCID

Affiliation:

1. Howard Hughes Medical Institute, Cornell University, Ithaca, NY 14853

2. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853

3. Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853

Abstract

Significance The study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.

Funder

HHS | National Institutes of Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2117013119

Reference37 articles.

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