Anterior thalamic circuits crucial for working memory-Reference-Cited by-同舟云学术

Anterior thalamic circuits crucial for working memory

Published:2022-05-10 Issue:20 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Roy Dheeraj S.¹^ORCID,Zhang Ying²,Aida Tomomi²,Shen Chenjie²^ORCID,Skaggs Keith M.²^ORCID,Hou Yuanyuan²,Fleishman Morgan¹,Mosto Olivia²^ORCID,Weninger Alyssa²,Feng Guoping¹²^ORCID

Affiliation:

1. Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142

2. McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139

Abstract

Significance Anterior thalamus exhibits significant functional changes with increasing age. While it has been associated with cognitive functions, the specific circuitry relevant for working memory remains unknown. The significance of this study is threefold: First, the anteroventral subdivision of anterior thalamic nuclei is necessary for working memory maintenance; second, aged mice showed a decrease in the excitability of anteroventral thalamic neurons, which correlated with a working memory impairment; and third, activating anteroventral thalamic neurons in aged mice was sufficient to improve their working memory.

Funder

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2118712119

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