A case of convergent evolution: Several viral and bacterial pathogens hijack RSK kinases through a common linear motif-Reference-Cited by-同舟云学术

A case of convergent evolution: Several viral and bacterial pathogens hijack RSK kinases through a common linear motif

Published:2022-01-28 Issue:5 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Sorgeloos Frédéric¹^ORCID,Peeters Michael¹²^ORCID,Hayashi Yohei¹³,Borghese Fabian¹,Capelli Nicolas¹,Drappier Melissa¹^ORCID,Cesaro Teresa¹,Colau Didier⁴^ORCID,Stroobant Vincent⁴,Vertommen Didier⁵⁶^ORCID,de Bodt Grégory¹,Messe Stéphane¹,Forné Ignasi⁷,Mueller-Planitz Felix⁷⁸,Collet Jean-François⁹¹⁰^ORCID,Michiels Thomas¹^ORCID

Affiliation:

1. Virology Unit (VIRO), de Duve Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium

2. Viral Diseases, Infectious Diseases in Humans, Sciensano 1050 Brussels, Belgium

3. Frontier Sciences Unit, Department of Medical Innovations, Otsuka Pharmaceutical Co., Ltd., Tokushima 771-0192, Japan

4. Brussels Branch, Ludwig Institute for Cancer Research, B-1200 Brussels, Belgium

5. Protein Phosphorylation Unit (PHOS), de Duve Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium

6. Mass spectrometry platform (MASSPROT), de Duve Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium

7. Molecular Biology, Biomedical Centre, Faculty of Medicine, Ludwig-Maximilians-Universität München, 82152 Martinsried, Germany

8. Faculty of Medicine Carl Gustav Carus, Institute of Physiological Chemistry, Technische Universität Dresden, 01307 Dresden, Germany

9. Welbio, B-1200 Brussels, Belgium

10. Biochemistry Unit (BCHM), de Duve Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium

Abstract

Significance Successful microbial infections typically involve the subversion of host immune pathways by pathogen-specific virulence factors. Here, we uncovered that viruses and bacteria independently evolved effectors targeting the same conserved loop of the mitogen-activated protein kinase (MAPK) p90-ribosomal S6-kinases (RSKs). Kinase usurpation relies on a previously unidentified short linear motif (SLiM) shared by these virulence factors. Mechanistically, RSK kinase binding prevents its dephosphorylation, thus promoting its phosphorylating activity. Remarkably, while viruses and bacteria evolved an identical mechanism of kinase activation, downstream effect diverged, effectively disarming different arms of the immune system according to their own need. This is a prominent illustration of trans-kingdom convergent evolution across microbial pathogens to usurp key signaling kinases.

Funder

EOS

Federaal Wetenschapsbeleid

Fonds De La Recherche Scientifique - FNRS

Communaute Francaise de Belgique

Era-Net

Deutsche Forschungsgemeinschaft

FNRS | Fonds pour la Formation à la Recherche dans l''''Industrie et dans l''''Agriculture

Koning Boudewijnstichting

Publisher

Proceedings of the National Academy of Sciences

Subject