Affiliation:
1. Department of Engineering, University of Cambridge, CB2 1PZ Cambridge, United Kingdom
Abstract
Significance
Biochemical reactions often occur in small volumes within a cell, restricting the number of molecules to the hundreds or even tens. At this scale, reactions are discrete and stochastic, making reliable signaling difficult. This paper shows that the transition between discrete, stochastic reactions and macroscopic reactions can be exploited to make a self-regulating switch. This constitutes a previously unidentified kind of reaction network that may be present in small structures, such as synapses.
Publisher
Proceedings of the National Academy of Sciences
Cited by
3 articles.
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