Dual-function AzuCR RNA modulates carbon metabolism-Reference-Cited by-同舟云学术

Dual-function AzuCR RNA modulates carbon metabolism

Published:2022-03-03 Issue:10 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Raina Medha¹,Aoyama Jordan J.¹²,Bhatt Shantanu¹,Paul Brian J.¹,Zhang Aixia¹,Updegrove Taylor B.³,Miranda-Ríos Juan¹,Storz Gisela¹^ORCID

Affiliation:

1. Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430

2. Biological Sciences Graduate Program, University of Maryland, College Park, MD 20740

3. Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892

Abstract

Significance While most small, regulatory RNAs are thought to be “noncoding,” a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2117930119

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