Testing fractional doses of COVID-19 vaccines-Reference-Cited by-同舟云学术

Testing fractional doses of COVID-19 vaccines

Published:2022-02-07 Issue:8 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Więcek Witold¹,Ahuja Amrita²,Chaudhuri Esha¹,Kremer Michael¹³⁴,Simoes Gomes Alexandre¹,Snyder Christopher M.⁴⁵,Tabarrok Alex⁶,Tan Brandon Joel⁷

Affiliation:

1. Development Innovation Lab, University of Chicago, Chicago, IL 60637

2. Douglas B. Marshall Jr. Family Foundation, Houston, TX 77002

3. Department of Economics, University of Chicago, Chicago, IL 60637

4. National Bureau of Economic Research, Cambridge, MA 02138

5. Department of Economics, Dartmouth College, Hanover, NH 03755

6. Department of Economics, George Mason University, Fairfax, VA 22030

7. Department of Economics, Harvard University, Cambridge, MA 02138

Abstract

Significance Switching to fractional doses could dramatically accelerate vaccination, and clinical evidence suggests that fractional doses of COVID-19 vaccines could be highly effective. However, there is uncertainty about the effectiveness of fractional doses. In this paper, we present the existing evidence and use epidemiological models to quantify benefits under various scenarios. We argue for more experimental or observational data to be collected urgently. Because switching to fractional dosing could dramatically accelerate vaccination, the potential benefits of further testing of fractional doses far outweigh the costs.

Funder

Wellspring Philanthropic Fund

Open Philanthropy

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2116932119

Reference52 articles.

1. G. Gopinath Reopening from the great lockdown: Uneven and uncertain recovery. IMF Blog (2020). https://blogs.imf.org/2020/06/24/reopening-from-the-great-lockdown-uneven-and-uncertain-recovery/. Accessed 14 September 2021.

2. The COVID-19 Pandemic and the $16 Trillion Virus

3. Market design to accelerate COVID-19 vaccine supply

4. Operation Warp Speed: implications for global vaccine security

5. N. Bariyo G. Steinhauser Covid-19 vaccine gap between rich and poor nations keeps widening. Wall Street Journal 25 September 2021. https://www.wsj.com/articles/covid-19-vaccine-gap-between-rich-and-poor-nations-keeps-widening-11632578312?mod=article_inline. Accessed 24 November 2021.

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