Affiliation:
1. Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892-4415
Abstract
Significance
Adolescence is a period during which there are important changes in behavior and the structure of the brain. In this manuscript, we use theoretical modeling to show how improvements in working memory and reinforcement learning that occur during adolescence can be explained by the reduction in synaptic connectivity in prefrontal cortex that occurs during a similar period. We train recurrent neural networks to solve working memory and reinforcement learning tasks and show that when we prune connectivity in these networks, they perform the tasks better. The improvement in task performance, however, can come at the cost of flexibility as the pruned networks are not able to learn some new tasks as well.
Funder
HHS | NIH | National Institute of Mental Health
Publisher
Proceedings of the National Academy of Sciences
Cited by
12 articles.
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