Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases-Reference-Cited by-同舟云学术

Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases

Published:2022-04-06 Issue:15 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Dai Yu-Ting¹,Zhang Fan¹,Fang Hai¹,Li Jian-Feng¹²^ORCID,Lu Gang¹,Jiang Lu¹,Chen Bing¹,Mao Dong-Dong¹,Liu Yuan-Fang¹,Wang Jin¹,Peng Li-Jun¹,Feng Chong¹²,Chen Hai-Feng³,Mu Jun-Xi³^ORCID,Zhang Qun-Ling⁴,Wang Hao⁵,Ariffin Hany⁶,Moy Tan Ah⁷,Wang Jing-Han⁸,Lou Yin-Jun⁸^ORCID,Chen Su-Ning⁹¹⁰,Wang Qian⁹,Liu Hong⁹,Shan Zhe⁹,Matsumura Itaru¹¹,Miyazaki Yasushi¹²,Yasuda Takahiko¹³,Dou Li-Ping⁵,Yan Xiao-Jing¹⁴,Yan Jin-Song¹⁵,Yeoh Allen Eng-Juh¹⁶¹⁷¹⁸,Wu De-Pei⁹¹⁰^ORCID,Kiyoi Hitoshi¹⁹,Hayakawa Fumihiko²⁰,Jin Jie⁸,Wang Sheng-Yue¹,Sun Xiao-Jian¹^ORCID,Mi Jian-Qing¹,Chen Zhu¹^ORCID,Huang Jin-Yan²¹²²,Chen Sai-Juan¹^ORCID

Affiliation:

1. Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China

2. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240 Shanghai, China

3. State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240 Shanghai, China

4. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, 200032 Shanghai, China

5. Department of Hematology, Chinese People’s Liberation Army General Hospital, 100853 Beijing, China

6. University of Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

7. Department of Paediatrics, KK Women’s & Children's Hospital, 229899 Singapore

8. Department of Hematology, The First Affiliated Hospital, Zhejiang University College of Medicine, 310058 Hangzhou, People’s Republic of China

9. National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, 215006 Suzhou, People’s Republic of China

10. Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, 215006 Suzhou, People’s Republic of China

11. Division of Hematology and Rheumatology, Kindai University Faculty of Medicine, 5778502 Osaka, Japan

12. Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, 8528521 Nagasaki, Japan

13. Clinical Research Center, Nagoya Medical Center, National Hospital Organization, 4600001 Nagoya, Japan

14. Department of Hematology, The First Affiliated Hospital of China Medical University, 110001 Liaoning, China

15. Department of Hematology, Second Hospital of Dalian Medical University, 116027 Leaoning, People’s Republic of China

16. Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore

17. Viva-University Children’s Cancer Centre, Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, 119074 Singapore

18. Cancer Science Institute of Singapore, National University of Singapore, 117599 Singapore

19. Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 4668550 Nagoya, Japan

20. Department of Integrated Health Sciences, Division of Cellular and Genetic Sciences, Nagoya University Graduate School of Medicine, 4610047 Nagoya, Japan

21. Center for Biomedical Big Data, The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, China

22. Cancer Center, Zhejiang University, 310058 Hangzhou, China

Abstract

Significance We provide transcriptomic insights into differences between pediatric and adult T cell acute lymphoblastic leukemia (T-ALL) patients through an international collaborative effort integrating RNA-sequencing data of 707 patients. Ten subtypes were identified, each characterized by distinct gene mutation profiles and dysregulated expression signatures of leukemogenic factors, and associated with T cell development stages. Adult T-ALL tends to have characteristics of early T cell precursor ALL, mostly corresponding to the mixed phenotype acute leukemia, whereas pediatric T-ALL shows a wide spectrum of aberrant molecular features, from early T cell precursor to mature T cell compartments. Our findings have important implications for disease mechanism of T-ALL that differs between pediatric and adult patients, facilitating further refined targeted therapy.

Funder

National Natural Science Foundation of China

the State Key Laboratory of Medical Genomics, the Double First-Class Project

the Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research

the Overseas Expertise Introduction Project for Discipline Innovation

the National Natural Science Foundation of China

), the Shanghai Shenkang Hospital Development Center (SHDC2), the Shanghai Major Project for Clinical Medicine

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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