Affiliation:
1. Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892
2. Department of Chemistry, Stanford University, Stanford, CA 94305
Abstract
Hydrogen peroxide (H
2
O
2
) plays a key role in environmental chemistry, biology, and medicine. H
2
O
2
concentrations typically are 6 to 10 orders of magnitude lower than that of water, making its quantitative detection challenging. We demonstrate that optimized NMR spectroscopy allows direct, interference-free, quantitative measurements of H
2
O
2
down to submicromolar levels in a wide range of fluids, ranging from exhaled breath and air condensate to rain, blood, urine, and saliva. NMR measurements confirm the previously reported spontaneous generation of H
2
O
2
in microdroplets that form when condensing water vapor on a hydrophobic surface, which can interfere with atmospheric H
2
O
2
measurements. Its antimicrobial activity and strong seasonal variation speculatively could be linked to the seasonality of respiratory viral diseases.
Funder
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
DOD | USAF | AFMC | Air Force Office of Scientific Research
Publisher
Proceedings of the National Academy of Sciences
Cited by
29 articles.
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