Cellular and transcriptional diversity over the course of human lactation-Reference-Cited by-同舟云学术

Cellular and transcriptional diversity over the course of human lactation

Published:2022-04-04 Issue:15 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Nyquist Sarah K.¹²³⁴,Gao Patricia³,Haining Tessa K. J.³,Retchin Michael R.³,Golan Yarden⁵,Drake Riley S.¹³⁶,Kolb Kellie¹³,Mead Benjamin E.¹³,Ahituv Nadav⁵^ORCID,Martinez Micaela E.⁷,Shalek Alex K.¹²³⁶⁸^ORCID,Berger Bonnie¹⁴,Goods Brittany A.⁹

Affiliation:

1. Broad Institute of MIT and Harvard, Cambridge, MA 02142

2. Program in Computational and Systems Biology, Massachusetts Institute of Technology; Cambridge, MA 02139

3. Department of Chemistry and Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139

4. Computer Science and Artificial Intelligence Laboratory, Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139

5. Department of Bioengineering and Therapeutic Sciences, Institute for Human Genetics, University of California, San Francisco, CA 94143

6. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139

7. Department of Biology, Emory University, Atlanta, GA 30322

8. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139

9. Thayer School of Engineering, Program in Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH 03755

Abstract

Significance Human breast milk is the nutritional food source evolved specifically to meet the needs of infants, but much remains to be learned about its composition and changes over the course of lactation. Our description of the cellular components of breast milk, their associations with maternal–infant dyad metadata, and quantification of alterations at the gene and pathway levels provide a longitudinal picture of human breast milk cells across lactational time. These results pave the way for improved therapeutic support of healthy lactation and milk production.

Funder

NIH

National Science Foundation

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2121720119

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2. How many child deaths can we prevent this year?