SNAT7 regulates mTORC1 via macropinocytosis-Reference-Cited by-同舟云学术

SNAT7 regulates mTORC1 via macropinocytosis

Published:2022-05-13 Issue:20 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Meng Delong¹²³,Yang Qianmei¹²³,Jeong Mi-Hyeon¹²³^ORCID,Curukovic Adna¹²³,Tiwary Shweta¹²³,Melick Chase H.¹²³^ORCID,Lama-Sherpa Tshering D.¹²³,Wang Huanyu¹²³,Huerta-Rosario Mariela²^ORCID,Urquhart Greg¹²³,Zacharias Lauren G.⁴,Lewis Cheryl²^ORCID,DeBerardinis Ralph J.⁴⁵,Jewell Jenna L.¹²³^ORCID

Affiliation:

1. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390

2. Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390

3. Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390

4. Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390

5. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390

Abstract

Significance The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway is frequently elevated in human disease, including cancer, type 2 diabetes, metabolic disorders, and neurodegeneration. We identify SNAT7 as an important regulator of mTORC1. We believe this research will provide valuable insight about mTORC1 biology and may uncover novel therapeutic targets for patients.

Funder

Cancer Prevention and Research Institute of Texas

The Welch Foundation

2017 UT Southwestern President''''s Research Council Distinguished Researcher Award

American Cancer Society

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Cancer Institute

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2123261119

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