The neural basis of swap errors in working memory

Abstract

When making decisions in a cluttered world, humans and other animals often have to hold multiple items in memory at once—such as the different items on a shopping list. Psychophysical experiments in humans and other animals have shown remembered stimuli can sometimes become confused, with participants reporting chimeric stimuli composed of features from different stimuli. In particular, subjects will often make “swap errors” where they misattribute a feature from one object as belonging to another object. While swap errors have been described behaviorally and theoretical explanations have been proposed, their neural mechanisms are unknown. Here, we elucidate these neural mechanisms by analyzing neural population recordings from monkeys performing two multistimulus working memory tasks. In these tasks, monkeys were cued to report the color of an item that either was previously shown at a corresponding location or will be shown at the corresponding location. Animals made swap errors in both tasks. In the neural data, we find evidence that the neural correlates of swap errors emerged when correctly remembered information is selected from working memory. This led to a representation of the distractor color as if it were the target color, underlying the eventual swap error. We did not find consistent evidence that swap errors arose from misinterpretation of the cue or errors during encoding or storage in working memory. These results provide evidence that swap errors emerge during selection of correctly remembered information from working memory, and highlight this selection as a crucial—yet surprisingly brittle—neural process.