Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference22 articles.
1. Targeting the Hedgehog pathway in cancer
2. Shifting paradigms in Hedgehog signaling
3. The dynamics of the cycle
4. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
5. Hedgehog regulates smoothened activity by inducing a conformational switch
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1. GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade;PLOS Biology;2024-08-13
2. Numb positively regulates Hedgehog signaling at the ciliary pocket;Nature Communications;2024-04-25
3. Towards modular engineering of cell signalling: Topographically-textured microparticles induce osteogenesis via activation of canonical hedgehog signalling;Biomaterials Advances;2023-11
4. Synthesis of Vismodegib Derivatives as Potential Smo Agonist: A Case of Undergraduate Experimental Teaching;Russian Journal of General Chemistry;2023-10
5. Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies;Signal Transduction and Targeted Therapy;2023-08-18
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