COP1 controls light-dependent chromatin remodeling

Author:

Wang Wenli1ORCID,Kim Junghyun1ORCID,Martinez Teresa S.1ORCID,Huq Enamul1ORCID,Sung Sibum1ORCID

Affiliation:

1. Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712

Abstract

Light is a crucial environmental factor that impacts various aspects of plant development. Phytochromes, as light sensors, regulate myriads of downstream genes to mediate developmental reprogramming in response to changes in environmental conditions. CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) is an E3 ligase for a number of substrates in light signaling, acting as a central repressor of photomorphogenesis. The interplay between phytochrome B (phyB) and COP1 forms an antagonistic regulatory module that triggers extensive gene expression reprogramming when exposed to light. Here, we uncover a role of COP1 in light-dependent chromatin remodeling through the regulation of VIL1 (VIN3-LIKE 1)/VERNALIZATION 5, a Polycomb protein. VIL1 directly interacts with phyB and regulates photomorphogenesis through the formation of repressive chromatin loops at downstream growth-promoting genes in response to light. Furthermore, we reveal that COP1 governs light-dependent formation of chromatin loop and limiting a repressive histone modification to fine-tune expressions of growth-promoting genes during photomorphogenesis through VIL1.

Funder

HHS | NIH | National Institute of General Medical Sciences

National Science Foundation

Publisher

Proceedings of the National Academy of Sciences

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