Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis-Reference-Cited by-同舟云学术

Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis

Published:2022-03-25 Issue:13 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Kandel Prasanna¹²^ORCID,Semerci Fatih³⁴,Mishra Rachana³⁴,Choi William⁴⁵,Bajic Aleksandar⁴⁶,Baluya Dodge⁷,Ma LiHua⁸,Chen Kevin⁹,Cao Austin C.¹⁰,Phongmekhin Tipwarin⁹,Matinyan Nick¹¹¹,Jiménez-Panizo Alba¹²,Chamakuri Srinivas²¹³,Raji Idris O.²,Chang Lyra²,Fuentes-Prior Pablo¹⁴^ORCID,MacKenzie Kevin R.²⁸¹³¹⁵,Benn Caroline L.¹⁶,Estébanez-Perpiñá Eva¹²,Venken Koen¹¹¹,Moore David D.¹¹⁴^ORCID,Young Damian W.¹²⁴¹⁰¹³,Maletic-Savatic Mirjana³⁴¹⁷¹⁸

Affiliation:

1. Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030

2. Department of Pharmacology & Chemical Biology, Baylor College of Medicine, Houston, TX 77030

3. Department of Pediatrics–Neurology, Baylor College of Medicine, Houston, TX 77030

4. Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030

5. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030

6. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030

7. Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030

8. NMR and Drug Metabolism Advanced Technology Cores, Baylor College of Medicine, Houston, TX 77030

9. Department of Biosciences, Rice University, Houston, TX 77005

10. Department of Chemistry, Rice University, Houston, TX 77005

11. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030

12. Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain

13. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030

14. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030

15. Molecular Basis of Disease, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain

16. Pfizer Regenerative Medicine, Cambridge CB21 6GP, United Kingdom

17. Center for Drug Discovery, Baylor College of Medicine, Houston, TX 77030

18. Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030

Abstract

Significance Adult hippocampal neurogenesis underpins learning, memory, and mood but diminishes with age and certain illnesses. The orphan nuclear receptor TLX/NR2E1 regulates neural stem and progenitor cell self-renewal and proliferation, but its orphan status has hindered its utilization as a therapeutic target to modulate adult neurogenesis. Here, we deorphanize TLX and report that oleic acid is an endogenous, metabolic ligand of TLX. These findings open avenues for future therapeutic modulation of TLX to counteract cognitive and mental decline in aging and diseases associated with decreased neurogenesis.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2023784119

Reference57 articles.

1. Are New Neurons Formed in the Brains of Adult Mammals?

2. The role of adult hippocampal neurogenesis in brain health and disease

3. Dynamics of Hippocampal Neurogenesis in Adult Humans

4. Human Hippocampal Neurogenesis Persists throughout Aging

5. A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. MicroRNAs: pioneering regulators in Alzheimer’s disease pathogenesis, diagnosis, and therapy;Translational Psychiatry;2024-09-10

2. Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools;Journal of Medicinal Chemistry;2024-09-05

3. Nuclear Receptors and the Hidden Language of the Metabolome;Cells;2024-07-31

4. Cerebellar granular neuron progenitors exit their germinative niche via BarH-like1 activity mediated partly by inhibition of T-cell factor;Development;2024-07-01

5. Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators;HISTOL HISTOPATHOL;2024