Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis

Author:

Kandel Prasanna12ORCID,Semerci Fatih34,Mishra Rachana34,Choi William45,Bajic Aleksandar46,Baluya Dodge7,Ma LiHua8,Chen Kevin9,Cao Austin C.10,Phongmekhin Tipwarin9,Matinyan Nick111,Jiménez-Panizo Alba12,Chamakuri Srinivas213,Raji Idris O.2,Chang Lyra2,Fuentes-Prior Pablo14ORCID,MacKenzie Kevin R.281315,Benn Caroline L.16,Estébanez-Perpiñá Eva12,Venken Koen111,Moore David D.114ORCID,Young Damian W.1241013,Maletic-Savatic Mirjana341718

Affiliation:

1. Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, TX 77030

2. Department of Pharmacology & Chemical Biology, Baylor College of Medicine, Houston, TX 77030

3. Department of Pediatrics–Neurology, Baylor College of Medicine, Houston, TX 77030

4. Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030

5. Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030

6. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030

7. Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030

8. NMR and Drug Metabolism Advanced Technology Cores, Baylor College of Medicine, Houston, TX 77030

9. Department of Biosciences, Rice University, Houston, TX 77005

10. Department of Chemistry, Rice University, Houston, TX 77005

11. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030

12. Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain

13. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030

14. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030

15. Molecular Basis of Disease, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain

16. Pfizer Regenerative Medicine, Cambridge CB21 6GP, United Kingdom

17. Center for Drug Discovery, Baylor College of Medicine, Houston, TX 77030

18. Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030

Abstract

Significance Adult hippocampal neurogenesis underpins learning, memory, and mood but diminishes with age and certain illnesses. The orphan nuclear receptor TLX/NR2E1 regulates neural stem and progenitor cell self-renewal and proliferation, but its orphan status has hindered its utilization as a therapeutic target to modulate adult neurogenesis. Here, we deorphanize TLX and report that oleic acid is an endogenous, metabolic ligand of TLX. These findings open avenues for future therapeutic modulation of TLX to counteract cognitive and mental decline in aging and diseases associated with decreased neurogenesis.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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