Mathematical model of chronic pancreatitis

Author:

Hao Wenrui,Komar Hannah M.,Hart Phil A.,Conwell Darwin L.,Lesinski Gregory B.,Friedman Avner

Abstract

Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede the development of CP. A better understanding of the pathology of CP is needed to facilitate improved diagnosis and treatment strategies for this disease. The present paper develops a mathematical model of CP based on a dynamic network that includes macrophages, pancreatic stellate cells, and prominent cytokines that are present at high levels in the CP microenvironment. The model is represented by a system of partial differential equations. The model is used to explore in silico potential drugs that could slow the progression of the disease, for example infliximab (anti-TNF-α) and tocilizumab or siltuximab (anti-IL-6/IL-6R).

Funder

NSF | Directorate for Mathematical and Physical Sciences

NIH

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference53 articles.

1. Lee P Stevens T (2014) Chronic pancreatitis. Cleveland Clin. http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/gastroenterology/chronic-pancreatitis/. Accessed April 17, 2017.

2. Video-assisted thoracoscopic splanchnicectomy for pain control in chronic pancreatitis;Huffman;Innovations,2006

3. The revised Atlanta classification for acute pancreatitis: updates in imaging terminology and guidelines

4. Animal models for investigating chronic pancreatitis

5. Freedman S Whitcomb D Grover S (2016) Treatment of chronic pancreatitis. UpToDate. https://www.uptodate.com/contents/treatment-of-chronic-pancreatitis. Accessed April 17, 2017.

Cited by 29 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3