Abstract
Following the April 16, 2020 release of theOpening Up America Againguidelines for relaxing coronavirus disease 2019 (COVID-19) social distancing policies, local leaders are concerned about future pandemic waves and lack robust strategies for tracking and suppressing transmission. Here, we present a strategy for triggering short-term shelter-in-place orders when hospital admissions surpass a threshold. We use stochastic optimization to derive triggers that ensure hospital surges will not exceed local capacity and lockdowns are as short as possible. For example, Austin, Texas—the fastest-growing large city in the United States—has adopted a COVID-19 response strategy based on this method. Assuming that the relaxation of social distancing increases the risk of infection sixfold, the optimal strategy will trigger a total of 135 d (90% prediction interval: 126 d to 141 d) of sheltering, allow schools to open in the fall, and result in an expected 2,929 deaths (90% prediction interval: 2,837 to 3,026) by September 2021, which is 29% of the annual mortality rate. In the months ahead, policy makers are likely to face difficult choices, and the extent of public restraint and cocooning of vulnerable populations may save or cost thousands of lives.
Funder
HHS | National Institutes of Health
DHS | Science and Technology Directorate
Publisher
Proceedings of the National Academy of Sciences
Reference22 articles.
1. An interactive web-based dashboard to track COVID-19 in real time
2. The White House andCenters for Disease Control andPrevention , Guidelines Opening Up America Again (US White House Office, 2020).
3. The effect of public health measures on the 1918 influenza pandemic in U.S. cities
4. The impacts of simultaneous disease intervention decisions on epidemic outcomes;Andrews;J. Theor. Biol.,2016
5. D. Z. Roth , B. Henry , “Social distancing as a pandemic influenza prevention measure” (National Collaborating Centre for Infectious Diseases, 2011). https://nccid.ca/publications/social-distancing-as-a-pandemic-influenza-prevention-measure. Accessed 5 May 2020.
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53 articles.
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