GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference31 articles.
1. Cost of rNTP/dNTP pool imbalance at the replication fork
2. The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents
3. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
4. The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells
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1. Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel;iScience;2024-02
2. Allosteric substrate activation of SAMHD1 shapes deoxynucleotide triphosphate imbalances by interconnecting the depletion and biosynthesis of different dNTPs;2023-11-14
3. Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1;Nucleic Acids Research;2023-11-01
4. Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels;mBio;2023-10-31
5. Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi–Goutières syndrome SAMHD1 dNTPase ortholog;Journal of Biological Chemistry;2023-09
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