GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference31 articles.
1. Cost of rNTP/dNTP pool imbalance at the replication fork
2. The Impact of Macrophage Nucleotide Pools on HIV-1 Reverse Transcription, Viral Replication, and the Development of Novel Antiviral Agents
3. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
4. The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells
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1. Molecular dynamics investigation of DNA fragments bound to the anti-HIV protein SAMHD1 reveals alterations in allosteric communications;Journal of Molecular Graphics and Modelling;2024-06
2. Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis;Nature Communications;2024-05-06
3. Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel;iScience;2024-02
4. Allosteric substrate activation of SAMHD1 shapes deoxynucleotide triphosphate imbalances by interconnecting the depletion and biosynthesis of different dNTPs;2023-11-14
5. Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1;Nucleic Acids Research;2023-11-01
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