Abstract
It is hypothesized that perinatal cerebellar injury leads to long-term functional deficits due to circuit dysmaturation. Using a novel integration of GCaMP6f fiber photometry with automated measurement of cerebellar behavior using the ErasmusLadder, we causally link cerebellar injury to altered Purkinje cell responses during maladaptive behavior. Chemogenetic inhibition of neonatal Purkinje cells is sufficient to phenocopy the effects of perinatal cerebellar injury. Our results uncover a direct link between perinatal cerebellar injury and activity-dependent maturation of cerebellar cortex.
Funder
HHS | NIH | National Institute of Neurological Disorders and Stroke
District of Columbia - Intellectual and Developmental Disabilities Research Center
Children's National Board of Visitors
Publisher
Proceedings of the National Academy of Sciences
Cited by
3 articles.
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