An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers-Reference-Cited by-同舟云学术

An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

Published:2022-04-06 Issue:15 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Marciniak Stephanie¹^ORCID,Bergey Christina M.¹²^ORCID,Silva Ana Maria³⁴⁵^ORCID,Hałuszko Agata⁶⁷^ORCID,Furmanek Mirosław⁶^ORCID,Veselka Barbara⁸⁹^ORCID,Velemínský Petr¹⁰^ORCID,Vercellotti Giuseppe¹¹¹²,Wahl Joachim¹³,Zariņa Gunita¹⁴,Longhi Cristina¹⁵,Kolář Jan¹⁶¹⁷^ORCID,Garrido-Pena Rafael¹⁸^ORCID,Flores-Fernández Raúl¹⁹^ORCID,Herrero-Corral Ana M.²⁰^ORCID,Simalcsik Angela²¹²²^ORCID,Müller Werner²³^ORCID,Sheridan Alison²⁴,Miliauskienė Žydrūnė²⁵^ORCID,Jankauskas Rimantas²⁵^ORCID,Moiseyev Vyacheslav²⁶,Köhler Kitti²⁷,Király Ágnes²⁷,Gamarra Beatriz²⁸²⁹^ORCID,Cheronet Olivia³⁰³¹,Szeverényi Vajk²⁷³²^ORCID,Kiss Viktória²⁷,Szeniczey Tamás³³,Kiss Krisztián³³³⁴^ORCID,Zoffmann Zsuzsanna K.³⁵,Koós Judit³⁶,Hellebrandt Magdolna³⁶,Maier Robert M.³⁷³⁸^ORCID,Domboróczki László³⁹,Virag Cristian⁴⁰,Novak Mario⁴¹^ORCID,Reich David³⁷³⁸⁴²⁴³⁴⁴^ORCID,Hajdu Tamás³³,von Cramon-Taubadel Noreen⁴⁵^ORCID,Pinhasi Ron³⁰³¹^ORCID,Perry George H.¹⁴⁶⁴⁷⁴⁸^ORCID

Affiliation:

1. Department of Anthropology, Pennsylvania State University, University Park, PA 16802

2. Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ 08854

3. Research Centre for Anthropology and Health (Centro de Investigação em Antropologia e Saúde - CIAS), Department of Life Sciences, University of Coimbra, Coimbra 3000-456, Portugal

4. Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Coimbra 3000-456, Portugal

5. Archeology Center of the University of Lisbon (UNIARQ), University of Lisbon, Lisbon 1600-214, Portugal

6. Institute of Archaeology, University of Wrocław, Wrocław 50-139, Poland

7. Archeolodzy.org Foundation, Wrocław 50-316, Poland

8. Department of Chemistry, Analytical Environmental and Geo-Chemistry Research Unit, Vrije Univeristeit Brussels, Brussels 1050, Belgium

9. Department of Art Studies and Archaeology, Maritime Cultures Research Institute, Vrije Univeristeit Brussels, Brussels 1050, Belgium

10. Department of Anthropology, National Museum, Prague 115-79, Czech Republic

11. Department of Anthropology, Ohio State University, Columbus, OH 43210

12. Institute for Research and Learning in Archaeology and Bioarchaeology, Columbus, OH 43215

13. Institute for Scientific Archaeology, Working Group Palaeoanthropology, University of Tübingen, Tübingen 72074, Germany

14. Institute of Latvian History, University of Latvia, Riga 1050, Latvia

15. Soprintendenza Archeologia, Belle Arti e Paesaggio, Rome 00186, Italy

16. Department of Vegetation Ecology, Institute of Botany of the Czech Academy of Sciences, Průhonice 252-43, Czech Republic

17. Institute of Archaeology and Museology, Masaryk University, Brno 602-00, Czech Republic

18. Department of Prehistory and Archaeology, Universidad Autónoma de Madrid, Madrid 28049, Spain

19. Professional archaeologist, Parla 28980, Spain

20. Department of Prehistory, Universidad Complutense de Madrid, Madrid 28040, Spain

21. Olga Necrasov Center for Anthropological Research, Romanian Academy - Iasi Branch, Iasi 700481, Romania

22. Orheiul Vechi Cultural-Natural Reserve, Orhei 3506, Republic of Moldova

23. Laboratoire d'archéozoologie, Université de Neuchâtel, Neuchâtel 2000, Switzerland

24. Department of Scottish History & Archaeology, National Museums Scotland, Edinburgh EH1 1JF, Scotland

25. Department of Anatomy, Histology and Anthropology, Vilnius University, Vilnius 01513, Lithuania

26. Department of Physical Anthropology, Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Sciences, St. Petersburg 199034, Russia

27. Institute of Archaeology, Research Centre for the Humanities, Eötvös Loránd Research Network, Budapest 1097, Hungary

28. Institut Català de Paleoecologia Humana i Evolució Social, Tarragona 43007, Spain

29. Departament d’Història i Història de l’Art, Universitat Rovira i Virgili, Tarragona 43003, Spain

30. Department of Evolutionary Anthropology, University of Vienna, Vienna 1030, Austria

31. Human Evolution and Archaeological Sciences (HEAS), University of Vienna, Vienna 1030, Austria

32. Department of Archaeology, Déri Múzeum, Debrecen 4026, Hungary

33. Department of Biological Anthropology, Eötvös Loránd University, Budapest 1053, Hungary

34. Department of Anthropology, Hungarian Natural History Museum, Budapest 1083, Hungary

35. Department of Archaeology, Hungarian National Museum, Budapest 1088, Hungary

36. Department of Archaeology, Herman Ottó Museum, Miskolc 3530, Hungary

37. Department of Genetics, Harvard Medical School, Boston, MA 02115

38. Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138

39. Department of Archaeology, István Dobó Castle Museum, Eger 3300, Hungary

40. Department of Archaeology, Satu Mare County Museum, Satu Mare 440031, Romania

41. Centre for Applied Bioanthropology, Institute for Anthropological Research, Zagreb 10000, Croatia

42. The Max Planck–Harvard Research Center for the Archaeoscience of the Ancient Mediterranean, Boston, MA 02115

43. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142

44. HHMI, Harvard Medical School, Cambridge, MA 02138

45. Buffalo Human Evolutionary Morphology Lab, Department of Anthropology, University at Buffalo, Buffalo, NY 14261-0026

46. Department of Biology, Pennsylvania State University, University Park, PA 16802

47. Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802

48. Deutsche Forschungsgemeinschaft (DFG) Center for Advanced Studies, University of Tübingen, Tübingen 72074, Germany

Abstract

SignificanceSubsistence shifts from hunting and gathering to agriculture over the last 12,000 y have impacted human culture, biology, and health. Although past human health cannot be assessed directly, adult stature variation and skeletal indicators of nonspecific stress can serve as proxies for health during growth and development. By integrating paleogenomic genotype and osteological stature data on a per-individual basis for 167 prehistoric Europeans, we observe relatively shorter than expected statures among early farmers after correcting for individual genetic contributions to stature. Poorer nutrition and/or increased disease burdens for early agriculturalists may partly underscore this result. Our integrated osteological–genetic model has exciting potential for studies of past human health and expansion into various other contexts.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2106743119

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