Affiliation:
1. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan
Abstract
Significance
The nervous system can store an experience of sensory stimulus. This function (i.e., learning) requires a robust molecular mechanism because accurate readout of information is crucial in survival. In this study, we found that the gustatory learning of
Caenorhabditis elegans
implemented as the amount of diacylglycerol in the sensory neuron can be read out not only by the activity of PKC-1, a protein kinase C, but also by that of another PKC, TPA-1. Because of its low sensitivity to diacylglycerol, TPA-1 does not function in the conventional learning assay. However, under conditions that may impair the system, such as aging, TPA-1 contributes to the learning. Our study shows the robustness of the learning system achieved by the two PKCs.
Funder
MEXT | Japan Society for the Promotion of Science
MEXT | JST | Core Research for Evolutional Science and Technology
Publisher
Proceedings of the National Academy of Sciences
Cited by
10 articles.
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