Regional synapse gain and loss accompany memory formation in larval zebrafish-Reference-Cited by-同舟云学术

Regional synapse gain and loss accompany memory formation in larval zebrafish

Published:2022-01-14 Issue:3 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Dempsey William P.¹,Du Zhuowei¹^ORCID,Nadtochiy Anna²^ORCID,Smith Colton D.¹,Czajkowski Karl³,Andreev Andrey²^ORCID,Robson Drew N.⁴,Li Jennifer M.⁴,Applebaum Serina¹^ORCID,Truong Thai V.²,Kesselman Carl³⁵,Fraser Scott E.¹²,Arnold Don B.¹^ORCID

Affiliation:

1. Department of Biological Sciences, Division of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089

2. Translational Imaging Center, University of Southern California, Los Angeles, CA 90089

3. Information Sciences Institute, University of Southern California, Los Angeles, CA 90292

4. Systems Neuroscience & Neuroengineering, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany

5. Daniel J. Epstein Department of Industrial and Systems Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089

Abstract

Significance Imaging of labeled excitatory synapses in the intact brain before and after classical conditioning permits a longitudinal analysis of changes that accompany associative memory formation. When applied to midlarval stage zebrafish, this approach reveals adjacent regions of synapse gain and loss in the lateral and medial pallium, respectively. Such major structural changes could account for the robust nature of memory formation from classical conditioning.

Funder

HHS | NIH | National Institute of Mental Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2107661119

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