Modeling suggests gene editing combined with vaccination could eliminate a persistent disease in livestock-Reference-Cited by-同舟云学术

Modeling suggests gene editing combined with vaccination could eliminate a persistent disease in livestock

Published:2022-02-25 Issue:9 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Petersen Gertje Eta Leony¹^ORCID,Buntjer Jaap B.²,Hely Fiona S.¹^ORCID,Byrne Timothy John³⁴,Doeschl-Wilson Andrea²^ORCID

Affiliation:

1. AbacusBio Ltd, Dunedin 9016, New Zealand

2. The Roslin Institute, University of Edinburgh, Easter Bush EH25 9RG, Scotland

3. AbacusBio International, Roslin Innovation Centre, The University of Edinburgh, Easter Bush EH25 9RG, Scotland

4. The Global Academy of Agriculture and Food Security, The University of Edinburgh, Easter Bush EH25 9RG, Scotland

Abstract

Significance This proof-of-concept modeling study offers quantitative insights into the potential epidemiological benefits of gene-editing technologies and how these may be most effectively implemented to control one of the most harmful pig diseases to date. In the future, the epidemiological benefits will need to be complemented by systematic assessment of economic and technological feasibility to enable balancing these against ethical and societal concerns.

Funder

UKRI Industry Strategic Challenge Fund

BBSRC Institute

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2107224119

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2. CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo