BEND3 safeguards pluripotency by repressing differentiation-associated genes-Reference-Cited by-同舟云学术

BEND3 safeguards pluripotency by repressing differentiation-associated genes

Published:2022-02-25 Issue:9 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Kurniawan Fredy¹,Chetlangia Neha¹,Kamran Mohammad¹^ORCID,Redon Christophe E.²,Pongor Lorinc²^ORCID,Sun Qinyu¹^ORCID,Lin Yo-Chuen¹,Mohan Vijay¹,Shaqildi Oways¹^ORCID,Asoudegi Darya¹^ORCID,Hao Qinyu¹,Khan Abid¹,Aladjem Mirit I.²^ORCID,Prasanth Kannanganattu V.¹³,Prasanth Supriya G.¹³

Affiliation:

1. Department of Cell and Developmental Biology, School of Molecular and Cellular Biology, University of Illinois at Urbana–Champaign, Urbana, IL 61801

2. Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892

3. Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, IL, 61801

Abstract

Significance The molecular basis of how the BEN domain–containing gene family regulates chromatin function and transcription remains to be elucidated. We report that BEND3 is highly expressed in pluripotent cells and binds to promoters of genes involved in differentiation. BEND3 regulates the expression of differentiation-associated genes by modulating the chromatin architecture at promoters. We propose that transcription repression mediated by BEND3 is essential for normal development and maintenance of pluripotency.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2107406119

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