Association of improved air quality with lower dementia risk in older women-Reference-Cited by-同舟云学术

Association of improved air quality with lower dementia risk in older women

Published:2022-01-04 Issue:2 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Wang Xinhui¹^ORCID,Younan Diana²^ORCID,Millstein Joshua²^ORCID,Petkus Andrew J.¹,Garcia Erika²^ORCID,Beavers Daniel P.³,Espeland Mark A.³^ORCID,Chui Helena C.¹,Resnick Susan M.⁴,Gatz Margaret⁵^ORCID,Kaufman Joel D.⁶⁷⁸^ORCID,Wellenius Gregory A.⁹,Whitsel Eric A.¹⁰¹¹^ORCID,Manson JoAnn E.¹²^ORCID,Rapp Stephen R.¹³¹⁴^ORCID,Chen Jiu-Chiuan¹²

Affiliation:

1. Department of Neurology, University of Southern California, Los Angeles, CA 90033;

2. Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032;

3. Department of Biostatistics and Data Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157;

4. Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224;

5. Center for Economic and Social Research, University of Southern California, Los Angeles, CA 90089;

6. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195;

7. Department of Medicine, University of Washington, Seattle, WA 98195;

8. Department of Epidemiology, University of Washington, Seattle, WA 98195;

9. Department of Environmental Health, Boston University, Boston, MA 02215;

10. Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC 27599;

11. Department of Medicine, UNC School of Medicine, Chapel Hill, NC 27516;

12. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115;

13. Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157;

14. Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC 27157

Abstract

Significance Epidemiological studies have demonstrated that improved air quality may improve respiratory health and reduce mortality. Increasing data support late-life exposure to air pollution as a modifiable risk factor for dementia, but whether improved ambient air quality translates to lower dementia risk is unclear. In this study on a geographically diverse cohort of US community-dwelling older women, we found that long-term improvement in ambient air quality in late life was associated with reduced dementia risk. The associations did not significantly differ by age, education, geographic region, Apolipoprotein E e4 genotypes, or cardiovascular risk factors. These findings strengthen the causal association between late-life exposure to air pollution and dementia risk.

Funder

HHS | NIH | National Institute of Environmental Health Sciences

HHS | NIH | National Institute on Aging

Alzheimer''''s Association

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2107833119

Reference57 articles.

1. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission