Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference40 articles.
1. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.
2. The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth.
3. Amplification of a gene encoding a p53-associated protein in human sarcomas
4. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
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