Abstract
Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However,Staphylococcus aureushas the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although manyS. aureushave this characteristic, some do not. The population dynamics regarding this defining trait have yet to be explored. We report here that coagulases are public goods that confer protection against antimicrobials and immune factors within a local population or community, thus promoting growth and virulence. By utilizing variants of a methicillin-resistantS. aureuswe infer that the secretion of coagulases is a cooperative trait, which is subject to exploitation by invading mutants that do not produce the public goods themselves. However, overexploitation, “tragedy of the commons,” does not occur at clinically relevant conditions. Our micrographs indicate this is due to spatial segregation and population viscosity. These findings emphasize the critical role of coagulases in a social evolution context and provide a possible explanation as to why the secretion of these public goods is maintained in mixedS. aureuscommunities.
Publisher
Proceedings of the National Academy of Sciences
Reference85 articles.
1. Guidelines for the prevention of intravascular catheter-related infections;O’Grady;MMWR Recomm Rep,2002
2. Registered Nurses’ Association of Ontario (2004) Assessment and device selection for vascular access (Registered Nurses’ Association of Ontario, Toronto).
3. Registered Nurses’ Association of Ontario (2005) Care and maintencance to reduce vascular access complications (Registered Nurses’ Association of Ontario, Toronto).
4. Prevalence of the Use of Central Venous Access Devices Within and Outside of the Intensive Care Unit: Results of a Survey Among Hospitals in the Prevention Epicenter Program of the Centers for Disease Control and Prevention
5. Guidelines for the Prevention of Intravascular Catheter-related Infections
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