Dominant negative mechanism of Presenilin-1 mutations in FAD
Author:
Funder
Office of Extramural Research, National Institutes of Health
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference20 articles.
1. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization
2. The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
3. Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration
4. Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice
5. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2
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