Hot-spot mutants of p53 core domain evince characteristic local structural changes
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference20 articles.
1. Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
2. The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.
3. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.
4. p53 domains: identification and characterization of two autonomous DNA-binding regions.
Cited by 195 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Canonical and non-canonical functions of p53 isoforms: potentiating the complexity of tumor development and therapy resistance;Cell Death & Disease;2024-06-12
2. p53 biology and reactivation for improved therapy in MDS and AML;Biomarker Research;2024-03-13
3. Conformational plasticity and allosteric communication networks explain Shelterin protein TPP1 binding to human telomerase;Communications Chemistry;2023-11-07
4. Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants;npj Breast Cancer;2023-09-29
5. Elucidating the Mechanisms of R248Q Mutation-Enhanced p53 Aggregation and Its Inhibition by Resveratrol;The Journal of Physical Chemistry B;2023-09-04
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3