Author:
Sanjak Jaleal S.,Sidorenko Julia,Robinson Matthew R.,Thornton Kevin R.,Visscher Peter M.
Abstract
Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features of contemporary human evolution. Here we leverage the UK Biobank data to test for the presence of linear and nonlinear natural selection in a contemporary population of the United Kingdom. We obtain phenotypic and genetic evidence consistent with the action of linear/directional selection. Phenotypic evidence suggests that stabilizing selection, which acts to reduce variance in the population without necessarily modifying the population mean, is widespread and relatively weak in comparison with estimates from other species.
Funder
Australian Research Council
Department of Health | National Health and Medical Research Council
HHS | National Institutes of Health
National Science Foundation
Publisher
Proceedings of the National Academy of Sciences
Cited by
104 articles.
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