ApoE influences amyloid- (A ) clearance despite minimal apoE/A association in physiological conditions
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
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1. Alzheimer's disease (AD) represents a pressing global health challenge with far-reaching socio-economic implications. Despite extensive research, the precise molecular mechanisms underlying its pathogenesis remain elusive. This study seeks to decipher the genomic symphony orchestrating the onset and progression of AD, shedding light on novel molecular targets for therapeutic intervention. AD is characterized by progressive cognitive decline, neuronal loss, and the accumulation of amyloid-beta plaques and neurofibrillary tangles. While several genetic risk factors have been identified, their interplay with environmental factors and epigenetic modifications remains poorly understood. This study aims to elucidate the intricate molecular networ (Preprint);2024-08-28
2. Trajectory of brain-derived amyloid beta in Alzheimer’s disease: where is it coming from and where is it going?;Translational Neurodegeneration;2024-08-19
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