Affiliation:
1. Friday Harbor Laboratories, University of Washington, Friday Harbor, WA 98250
Abstract
Significance
The genome of insects with complete metamorphosis contains the instructions for making three distinct body forms, that of the larva, of the pupa, and of the adult. However, the molecular mechanisms by which each gene set is called forth and stably expressed are poorly understood. A half century ago, it was proposed that there was a set of three master genes that inhibited each other’s expression and enabled the expression of genes for each respective stage. We show that the transcription factor
chinmo
is essential for maintaining the larval stage in
Drosophila
, and with two other regulatory genes,
broad
and
E93
, makes up the trinity of mutually repressive master genes that underlie insect metamorphosis.
Funder
Howard Hughes Medical Institute
Publisher
Proceedings of the National Academy of Sciences
Cited by
10 articles.
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