A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation
Author:
Affiliation:
1. Department of Life Sciences, Imperial College London, Ascot SL5 7PY, United Kingdom
2. Chromosome Segregation Laboratory, and Mechanobiology and Biophysics Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom
Abstract
Funder
Bill and Melinda Gates Foundation
Open Philanthropy Project
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Link
https://pnas.org/doi/pdf/10.1073/pnas.2200567119
Reference40 articles.
1. Site-specific selfish genes as tools for the control and genetic engineering of natural populations
2. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
3. The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito
4. A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes
5. Vector control with driving Y chromosomes: modelling the evolution of resistance
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