Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference29 articles.
1. Active human immunodeficiency virus protease is required for viral infectivity.
2. Conformational aspects of inhibitor design: enzyme–substrate interactions in the transition state
3. INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design
4. Stability and activity of human immunodeficiency virus protease: comparison of the natural dimer with a homologous, single-chain tethered dimer.
5. Observation of a tetrahedral reaction intermediate in the HIV-1 protease–substrate complex
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