Expression of Matrix Metalloproteinases in Thyroid Follicular Neoplasm Fnab

Abstract

Fine-Needle Aspiration Biopsy (FNAB) thyroid nodules is difficult to distinguish betwen follicular malignancy and follicular benign lesion (1). The diagnosis of malignancy can only be made from histopathology examination by examing tumor invation to capsule and vascular (2,3). Matrix Metalloproteinase 9 (MMP-9) examination can be added to help making initial diagnosis. MMP-9 is a proteolytic enzyme that plays important role in cancer progressivity, especially in thyroid. High MMP-9 expression will lead to earlier degradation of thyroid and its will make the cell metastasist easier (4). This study aims to examine MMP-9 expression of thyroid follicular neoplasm FNAB. We used 42 sample of follicular thyroid neoplasm FNAB obtained from the Pathology Anatomic laboratories in RSUP M Djamil Padang, West Sumatera. Immunohistochemical was staining with primary antibody MMP-9 then its expression were assessed in stroma and cytoplasmic tumour. In this study FNAB follicular thyroid nodules were found in the age group 21-45 years (57.1%), women (88.1%), and MMP-9 expression was found as much as 80.9%.