Dispersion of Alpha-Nuclides during Animal Experiments

Author:

KANEDA-NAKASHIMA Kazuko1,ZHANG Zijian2,NAGATA Kojiro3,SHIRASAKI Kenji4,KIKUNAGA Hidetoshi5,YAMAMURA Tomoo6,OOE Kazuhiro7,WATABE Tadashi7,TOYOSHIMA Atsushi2,YOSHIMURA Takashi2,SHINOHARA Atsushi2

Affiliation:

1. Division of Science, Institute for Radiation Sciences, Osaka University

2. Project Research Center for Fundamental Sciences, Graduate School of Science, Osaka University

3. Radioisotope Research Center, Institute for Radiation Sciences, Osaka University

4. Laboratory of Alpha-Ray Emitters, Institute for Materials Research, Tohoku University

5. Research Center for Electron Photon Science, Tohoku University

6. Institute for Integrated Radiation and Nuclear Science, Kyoto University

7. Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University

Publisher

Japanese Society of Radiation Safety Management

Subject

General Medicine

Reference20 articles.

1. 1) Ministry of Health, Labor and Welfare “Nationwide cancer incidence number 2016 preliminary report”, https://www.mhlw.go.jp/content/10900000/000468976.pdf

2. 2) Xofigo, for intravenous injection (radiopharmaceutical standard radium chloride (223Ra) injection solution) package insert, https://pharma-navi.bayer.jp/omr/online/product_material/XOF_MPI_201810050_1538444913.pdf

3. 3) Henriksen G, Breistøl K, Bruland ØS, Fodstad Ø, Larsen RH: Significant antitumor effect from bone-seeking, alpha-particle-emitting (223)Ra demonstrated in an experimental skeletal metastases model, Cancer Res., 62, 3120-5 (2002).

4. 4) Bruland ØS, Nilsson S, Fisher DR, Larsen RH: High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?, Clin Cancer Res., 12, 6250s-6257s (2006).

5. 5) Kratochwil C, Bruchertseifer F, Giesel FL, Weis M, Verburg FA, Mottaghy F, Kopka K, Apostolidis C, Haberkorn U, Morgenstern A: 225Ac-PSMA-617 for PSMA-Targeted α-Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer., J Nucl Med., 57, 1941-1944 (2016).

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