Abstract
The renin-angiotensin system plays a crucial role in maintaining homeostasis of
the cardiovascular system, and there have been studies on its relevance to the
onset of Kawasaki disease and coronary artery complications. However, there is
still a lack of sufficient and consistent research data regarding the diagnosis
and prognostication of Kawasaki disease using the genetic/serologic biomarkers
associated with this system. The use of angiotensin-converting enzyme inhibitors
or angiotensin receptor blockers as therapeutic agents also lacks substantial
experimental and clinical evidence. According to the JCS/JSCS guideline, in the
case of patients with coronary artery aneurysms, the use of these medications in
combination with other conventional treatments could be considered with the
consent of the patient/guardians.
Publisher
Korean Society of Kawasaki Disease