Prenatal Exposure to Maternal Cigarette Smoking and DNA Methylation: Epigenome-Wide Association in a Discovery Sample of Adolescents and Replication in an Independent Cohort at Birth through 17 Years of Age

Author:

Lee Ken W.K.1,Richmond Rebecca2,Hu Pingzhao13,French Leon4,Shin Jean1,Bourdon Celine1,Reischl Eva5,Waldenberger Melanie56,Zeilinger Sonja5,Gaunt Tom2,McArdle Wendy2,Ring Susan2,Woodward Geoff2,Bouchard Luigi78,Gaudet Daniel89,Smith George Davey2,Relton Caroline210,Paus Tomas4,Pausova Zdenka1

Affiliation:

1. The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

2. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom

3. Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada

4. Rotman Research Institute, University of Toronto, Toronto, Ontario, Canada

5. Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, Munich, Germany

6. Institute of Epidemiology II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany

7. Department of Biochemistry, Université de Sherbrooke, Sherbrooke, Quebec, Canada

8. ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Quebec, Canada

9. Department of Medicine, Université de Montréal, Montréal, Quebec, Canada

10. Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference50 articles.

1. Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development

2. Individual common variants exert weak effects on the risk for autism spectrum disorders

3. ARIES. 2014. ARIES: Accessible Resource for Integrated Epigenomic Studies. Homepage. Available: http://www.ariesepigenomics.org.uk/ [accessed 24 June 2013].

4. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

5. Controlling the false discovery rate: a practical and powerful approach to multiple testing.;Benjamini Y;J R Stat Soc Series B Stat Methodol,1995

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