A Novel Two-Step Hierarchical Quantitative Structure–Activity Relationship Modeling Work Flow for Predicting Acute Toxicity of Chemicals in Rodents-Reference-Cited by-同舟云学术

A Novel Two-Step Hierarchical Quantitative Structure–Activity Relationship Modeling Work Flow for Predicting Acute Toxicity of Chemicals in Rodents

Published:2009-08 Issue:8 Volume:117 Page:1257-1264
ISSN:0091-6765
Container-title:Environmental Health Perspectives
language:en
Short-container-title:Environmental Health Perspectives

Author:

Zhu Hao¹,Ye Lin¹,Richard Ann²,Golbraikh Alexander¹,Wright Fred A.³,Rusyn Ivan⁴,Tropsha Alexander¹

Affiliation:

1. Laboratory for Molecular Modeling, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

3. Department of Biostatistics and

4. Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference36 articles.

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2. Metabolism and toxicology of heterocyclic aromatic amines when consumed in diet: Influence of the genetic susceptibility to develop human cancer. A review

3. The Expanding Role of Predictive Toxicology: An Update on the (Q)SAR Models for Mutagens and Carcinogens

4. In vitro cytotoxicity as a marker of hypersensitivity to sulphamethoxazole in patients with HIV

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