Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.-Reference-Cited by-同舟云学术

Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.

Published:1996-03 Issue:suppl 1 Volume:104 Page:123-134
ISSN:0091-6765
Container-title:Environmental Health Perspectives
language:en
Short-container-title:Environmental Health Perspectives

Author:

Melnick R L¹,Kohn M C¹,Portier C J¹

Affiliation:

1. Laboratory of Quantitative and Computational Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference161 articles.

1. is detected statistically as that dose below Is the mechanism biologically plausible?

2. which the activity of a biomarker for the Are the data of sufficient quality to

3. response in treated subjects is indistin- reasonably link the specific mechanistic

4. guishable from that in controls. However process to the cancer outcome?

5. attribution of a threshold in such circum- Are competing explanations valid?

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