COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP.

Author:

Lewis D F1,Ioannides C1,Parke D V1

Affiliation:

1. School of Biological Sciences, University of Surrey, Guildford, United Kingdom. dlewis@surrey.ac.uk

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference33 articles.

1. positive by metal ion redox potential were fatal. The supplementation of COMPACT

2. nos. 12 21 and 30. to include metals by prediction of poten-Although we are primarily concerned in tial carcinogenicity from redox potentials

3. the identification of potential carcinogens and the likelihood of oxygen radical gener

4. the use of COMPACT to identify sub- ation together with a combination with

5. strates of CYPIA and/or CYP2E enables Hazardexpert and short-term mutagenicity

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