1,3-Butadiene: linking metabolism, dosimetry, and mutation induction.

Author:

Bond J A1,Csanady G A1,Gargas M L1,Guengerich F P1,Leavens T1,Medinsky M A1,Recio L1

Affiliation:

1. Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709.

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference64 articles.

1. factor rather than the quantity of the cals The present study was initiated to

2. enzyme present. begin to establish in vivo linkages between The simulations regarding the potential exposure to BD internal dose and a bio

3. interactions of styrene exposures on BD logical response (mutation). The induction

4. metabolism and vice versa used a strictly of mutations is a determinant of BD

5. competitive inhibition model and suggested induced carcinogenicity. Although the pre

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