1. organs in the neonatal animal) or regenera- promoting activity whereas initiation
2. tive hyperplasia after cell damage (urine seems to be correlated with formation of
3. bladder) formation of only this type of nonacetylated DNA adducts. At present
4. adducts may be sufficient for carcinogenesis. the exact mechanism by which formation In conclusion we have found a correlation of clastogenic DNA adducts may cause
5. between the formation of clastogenic N- hepatic promotion is not yet clear.