1. inhibitor of prostaglandin biosynthesis in Nevertheless the Iung damage imposed by
2. vitro (28) but rather increases the produc- ischemia reperfusion could be the concom
3. tion of prostacyclin (29). Our data demon- mitant actions of both toxic oxygen prod
4. strate that all these antiarrhythmic drugs ucts (21) and cyclooxygenase metabolites
5. inhibit cyclooxygenase product formation. (23). We conclude that the inhibition of