1. and the p5O-p65 heterodimer migrates into the appearance of vascular protein and cyto
2. the nucleus and turns on the genes of the plasmic enzymes within the airspaces. Since
3. inflammatory cascade (22). In mature the silica is not removed or detoxified by
4. macrophages this mechanism is activated phagocytosis the inflammation persists
5. without protein synthesis so it can act very within the Iungs leading to the eventual