Use of Shotgun Metagenomics and Metabolomics to Evaluate the Impact of Glyphosate or Roundup MON 52276 on the Gut Microbiota and Serum Metabolome of Sprague-Dawley Rats

Author:

Mesnage Robin1,Teixeira Maxime2,Mandrioli Daniele3,Falcioni Laura3,Ducarmon Quinten Raymond4,Zwittink Romy Daniëlle4,Mazzacuva Francesca5,Caldwell Anna5,Halket John5,Amiel Caroline2,Panoff Jean-Michel2,Belpoggi Fiorella3,Antoniou Michael Nicolas1

Affiliation:

1. Gene Expression and Therapy Group, Department of Medical and Molecular Genetics, King’s College London, Faculty of Life Sciences & Medicine, Guy’s Hospital, London, UK

2. Unité de Recherche Aliments Bioprocédés Toxicologie Environnements, University of Caen Normandy, Caen, France

3. Ramazzini Institute, Bologna, Italy

4. Center for Microbiome Analyses and Therapeutics, Leiden University Medical Center, Leiden, Netherlands

5. Mass Spectrometry Facility, King’s College London, London, UK

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference87 articles.

1. Abraham W inventor; Monsanto Technology LLC assignee. Glyphosate formulations and their use for the inhibition of 5-enolpyruvylshikimate-3-phosphate synthase. US patent 7 771 736. 10 August 2010.

2. The oral and intratracheal toxicities of ROUNDUP and its components to rats;Adam A;Vet Hum Toxicol,1997

3. Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats

4. Glyphosate-Induced Specific and Widespread Perturbations in the Metabolome of Soil Pseudomonas Species

5. Oxidative Degradation of Glyphosate and Aminomethylphosphonate by Manganese Oxide

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