A nonlinear dosimetric model for hemoglobin adduct formation by the neurotoxic agent acrylamide and its genotoxic metabolite glycidamide.

Author:

Calleman C J1,Bergmark E1,Stern L G1,Costa L G1

Affiliation:

1. Department of Environmental Health, University of Washington, Seattle 98195.

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference10 articles.

1. Office ofToxic Substances. Preliminary Assessment of Health Risks from Exposure to Acrylamide. U.S. Environmental Protection Agency Washington DC 1988.

2. Acrylamide: its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicity

3. Monitoring exposure to acrylamide by the determination of S-(2-carboxyethyl)cysteine in hydrolyzed hemoglobin by gas chromatography-mass spectrometry

4. Acrylamide is metabolized to glycidamide in the rat: evidence from hemoglobin adduct formation

5. Costa L. G. Deng H. Gregotti C. Manzo L. Faustman E. F. Bergmark E. and Calleman C. J. Comparative studies on the neuro- and reproductive toxicity of acrylamide and its epoxide metabolite glycidamide in the rat. In: Proceedings ofthe 3rd International Neurotoxicology Association Meeting Salsomaggiore Italy July 1991.

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