1. synthesis should at most be considered porphyria (or any less defined pathologic
2. speculative and unestablished. In cases disturbance of heme synthesis) or to use
3. involving these otherwise unexplained ill- such diagnoses as specific justification for
4. nesses and when there is no demonstrable lifestyle alterations or therapeutic interven
5. substantial accumulation or increased tions; porphyria-specific interventions