The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics.

Author:

Seidegård J1,Ekström G1

Affiliation:

1. Human Pharmacology at Astra Draco AB, Lund, Sweden. janeric.seidegard@clraco.se.astra.com

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

Reference113 articles.

1. detected at residues 113 and 139 did not These genetic and regulatory factors are

2. exert a primary influence on catalytic func- therefore likely to play a significant role in

3. tion but may affect the stability of mEH the response of individuals to many exoge

4. protein (63). The entire EPHXI gene has nous as well as endogenous compounds.

5. been cloned and sequenced (101). Results Deficiencies of particular enzymes may

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